Argyreia nervosa belonging to family Convolvulaceae which is distributed throughout India. The cardiotonic effect of infusion of whole plant of Argyreia nervosa was studied by using perfused frog heart assembly. In the present work different dilution of infusion A1 (undiluted), A2 (1:1 Filtrate: distilled water), A3 (1:2 Filtrate: distilled water), A4 (1:4 Filtrate: distilled water), are used to evaluate cardiac activity on isolated frog heart and compared with Digoxin B1-25µg/ml, B2-50µg/ml as a standard. Present preliminary studies confirm better cardiotonic activity of Argyreia nervosa than digoxin. A significant increase in height of force of contraction (positive ionotropic effect) and decrease in heart rate (negative chronotropic effect) was observed. Thus, in future it will be interesting to isolate the active chemical constituents which are responsible for the cardiotonic activity.
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